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Efficient Synthesis of Pamidronic Acid Using an Ionic Liquid Additive

[ Vol. 13 , Issue. 6 ]


Alajos Grun, Dávid Illés Nagy, Sándor Garadnay, István Greiner and Gyorgy Keglevich   Pages 475 - 478 ( 4 )


An efficient method was developed for the synthesis of pamidronic acid involving the reaction of β-alanine with three equivalents of phosphorus trichloride and two equivalents of phosphorous acid at 75 °C in the presence of 0.3 or 0.6 equivalents of [BMIM][PF6] as an additive.


Pamidronic acid, best synthesis, additive, ionic liquids, intermediate.


Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1521 Budapest, Hungary.

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