Article Details


Synthesis and Antiproliferative Activities of Novel O-Benzyl Salicylamide Derivatives

[ Vol. 14 , Issue. 6 ]

Author(s):

Jan Dusek, Ales Imramovsky, Karel Pauk, Radek Jorda, Eva Reznickova and Vladimir Krystof   Pages 662 - 671 ( 10 )

Abstract:


Background: On the basis that various substituted salicylamides have shown interesting biological properties, we designed and synthesized new salicylamide derivatives with dipeptide moieties.

Methods: The synthesis was based on the gradual building of target molecules and provided optically pure compounds.

Conclusion: The obtained compounds were tested for their antiproliferative effect against three leukaemia cell lines in vitro and displayed GI50 values in the mid-micromolar range.

Keywords:

Salicylamides, antiproliferative activity, cytotoxic activity, pharmacological activity, amines.

Affiliation:

Institute of Organic Chemistry and Technology, Faculty of Chemical Technology, University of Pardubice, Studentská 573, 53210 Pardubice, Institute of Organic Chemistry and Technology, Faculty of Chemical Technology, University of Pardubice, Studentská 573, 532 10 Pardubice, Institute of Organic Chemistry and Technology, Faculty of Chemical Technology, University of Pardubice, Studentská 573, 53210 Pardubice, Laboratory of Growth Regulators, Centre of the Region Haná for Biotechnological and Agricultural Research, Palacky University & Institute of Experimental Botany ASCR, Šlechtitelů 27, 78371 Olomouc, Laboratory of Growth Regulators, Centre of the Region Haná for Biotechnological and Agricultural Research, Palacky University & Institute of Experimental Botany ASCR, Šlechtitelů 27, 78371 Olomouc, Laboratory of Growth Regulators, Centre of the Region Haná for Biotechnological and Agricultural Research, Palacky University & Institute of Experimental Botany ASCR, Šlechtitelů 27, 78371 Olomouc

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