Ligia Souza da Silveira Pinto, Marcus V. N. de Souza* and Carlos R. Kaiser Pages 678 - 685 ( 8 )
Background: In continuation of our research on sonochemistry and due to the importance and application of hydrazones and N-acylhydrazones in drug discovery, in this work we report a new general and efficient synthesis of these classes with different aromatic and heteroaromatic nucleus assisted by ultrasound and their respective anti-tuberculosis and anti-cancer activities.Method: Derivatives 7-chloroquinoline 10 and 12 were the most promising compounds against cancer and TB, respectively. Conclusion: Unfortunately all new hydrazones and N-acylhydrazones evaluated displayed no activity anti cancer and TB.
Hydrazones, N-acylhydrazones, sonochemistry, anti-tuberculosis and anti-cancer activities, drug discovery.
Departamento de Química Orgânica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Instituto de Tecnologia em Fármacos-Far-Manguinhos, FioCruz-Fundação Oswaldo Cruz, P.O. Box: 21041- 250, Rio de Janeiro, Departamento de Química Orgânica, Universidade Federal do Rio de Janeiro, Rio de Janeiro