Article Details


Synthesis and Evaluation of Anti-Tuberculosis and Anti-Cancer Activities of Hydrazones and N-Acylhydrazones by Using Sonochemistry, A New General Procedure

[ Vol. 14 , Issue. 6 ]

Author(s):

Ligia Souza da Silveira Pinto, Marcus V. N. de Souza and Carlos R. Kaiser   Pages 678 - 685 ( 8 )

Abstract:


Background: In continuation of our research on sonochemistry and due to the importance and application of hydrazones and N-acylhydrazones in drug discovery, in this work we report a new general and efficient synthesis of these classes with different aromatic and heteroaromatic nucleus assisted by ultrasound and their respective anti-tuberculosis and anti-cancer activities.

Method: Derivatives 7-chloroquinoline 10 and 12 were the most promising compounds against cancer and TB, respectively.

Conclusion: Unfortunately all new hydrazones and N-acylhydrazones evaluated displayed no activity anti cancer and TB.

Keywords:

Hydrazones, N-acylhydrazones, sonochemistry, anti-tuberculosis and anti-cancer activities, drug discovery.

Affiliation:

Departamento de Química Orgânica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Instituto de Tecnologia em Fármacos-Far-Manguinhos, FioCruz-Fundação Oswaldo Cruz, P.O. Box: 21041- 250, Rio de Janeiro, Departamento de Química Orgânica, Universidade Federal do Rio de Janeiro, Rio de Janeiro

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