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Novel Chromeno[2,3-d]pyrimidines-Design, Synthesis and Antioxidant Activity

[ Vol. 14 , Issue. 7 ]

Author(s):

Kotiah Yalagala, Sreekantha B. Jonnalagadda*, Suresh Maddila, Surjyakanta Rana and Surya Narayana Maddila   Pages 763 - 772 ( 10 )

Abstract:


Introduction: Fourteen novel 8,8-dimethyl-8,9-dihydro-5H-chromeno[2,3-d]pyrimidin-6(7H)- one derivatives were rationally designed and synthesized successfully. The synthetic procedures adopted for the target molecules were achieved by facile protocols and the yields were good to excellent (> 80%).

Method: All the synthesized compounds were characterized by 1H NMR, 13C NMR, HR-MS and FT-IR spectral analysis. All new compounds were evaluated for their in vitro antioxidant activity by using DPPH, ABTS, NO and H2O2 methods.

Results: Among the novel derivatives, two of the synthesized compounds exhibited good antioxidant activities similar to ascorbic acid, in all the four tested methods.

Keywords:

Pyrimidines, synthesis, anti-oxidant activity, simple method, in vitro studies, human body.

Affiliation:

School of Chemistry & Physics, University of KwaZulu-Natal, Westville Campus, Chiltern Hills, Durban-4000, School of Chemistry & Physics, University of KwaZulu-Natal, Westville Campus, Chiltern Hills, Durban-4000, School of Chemistry & Physics, University of KwaZulu-Natal, Westville Campus, Chiltern Hills, Durban-4000, School of Chemistry & Physics, University of KwaZulu-Natal, Westville Campus, Chiltern Hills, Durban-4000, School of Chemistry & Physics, University of KwaZulu-Natal, Westville Campus, Chiltern Hills, Durban-4000

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