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Ultrasound Assisted Synthesis of 2-alkynyl Pyrazolo[1,5-a]pyrimidines as Potential Anti-cancer Agents

[ Vol. 14 , Issue. 10 ]

Author(s):

Yarlagadda Bharath, Mandava V. Basaveswara Rao* and Manojit Pal*   Pages 1206 - 1214 ( 9 )

Abstract:


Background: The 2-alkynyl pyrazolo[1,5-a]pyrimidine derivatives have been explored as new and potential anti-proliferative agents.

Methods: Ultrasound assisted synthesis of these compounds was carried out by using a multi-step method involving the H3PO3 mediated construction of pyrazolo[1,5-a]pyrimidine ring possessing a bromo group at C-2 position followed by Pd/C-Cu catalyzed alkynylation methodology as the key steps.

Results and Conclusion: All these compounds showed selective growth inhibition of cancer cell lines when tested against MDA-MB 231 and K562 cell lines along with non-cancerous HEK293 cells.

Keywords:

Pyrazolo[1, 5-a]pyrimidine, Pd/C, coupling, ultrasound, cancer, anticancer agents.

Affiliation:

Department Science and Humanities, Chemistry Division, Vignan’s Foundation for Science Technology and Research, University (VFSTR) University, Vadlamudi, Guntur-522 213, Andhra Pradesh, Department of Chemistry, Krishna University, Krishna District, Andhra Pradesh, Dr. Reddy’s Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad 500 046

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