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Arginine- and Lysine-rich Peptides: Synthesis, Characterization and Antimicrobial Activity

[ Vol. 15 , Issue. 3 ]

Author(s):

Adriano Mollica*, Giorgia Macedonio, Azzurra Stefanucci, Roberto Costante, Simone Carradori, Valentina Cataldi, Mara Di Giulio, Luigina Cellini, Romano Silvestri, Cesare Giordano, Anita Scipioni, Stefano Morosetti, Pasqualina Punzi and Sako Mirzaie   Pages 220 - 226 ( 7 )

Abstract:


Background: In recent years, the multi-drug resistance of bacteria and fungi strains has become a worldwide problem. The incidence of fungal and bacterial infections is experiencing a serious growth and the microorganisms have developed several new mechanisms of antibiotic resistance.

Methods: Antimicrobial peptides (AMPs) constitute one of the well-known barrier defense systems of plants. They have been isolated from roots, seeds, flowers, stems and leaves of a wide variety of species and have activities towards phytopathogens, as well as against human pathogens. AMPs are often cationic peptides able to interact with the membrane through penetration or dissolving the biofilms.

Results and Conclusion: In this paper, we report the synthesis of several arginine and lysine-rich peptides and their evaluation as antimicrobial agents.

Keywords:

AMPs, peptides, lysine- and arginine-rich peptides, Candida spp., multi-drug resistance, microorganisms.

Affiliation:

Dipartimento di Farmacia, Universita di Chieti-Pescara “G. d'Annunzio”, Via dei Vestini 31, 66100 Chieti, Dipartimento di Farmacia, Universita di Chieti-Pescara “G. d'Annunzio”, Via dei Vestini 31, 66100 Chieti, Dipartimento di Chimica, Sapienza Universita di Roma, P.le A. Moro, 5, 00187 Rome, Dipartimento di Farmacia, Universita di Chieti-Pescara “G. d'Annunzio”, Via dei Vestini 31, 66100 Chieti, Dipartimento di Farmacia, Universita di Chieti-Pescara “G. d'Annunzio”, Via dei Vestini 31, 66100 Chieti, Dipartimento di Farmacia, Universita di Chieti-Pescara “G. d'Annunzio”, Via dei Vestini 31, 66100 Chieti, Dipartimento di Farmacia, Universita di Chieti-Pescara “G. d'Annunzio”, Via dei Vestini 31, 66100 Chieti, Dipartimento di Farmacia, Universita di Chieti-Pescara “G. d'Annunzio”, Via dei Vestini 31, 66100 Chieti, Dipartimento di Chimica e Tecnologia del Farmaco, Sapienza Universita di Roma, P.le A. Moro, 5, 00187 Rome, Istituto di Biologia e Patologia Molecolare del CNR, Universita degli Studi La Sapienza, Piazzale Aldo Moro, 5, I-00185 Rome, Dipartimento di Chimica, Sapienza Universita di Roma, P.le A. Moro, 5, 00187 Rome, Dipartimento di Chimica, Sapienza Universita di Roma, P.le A. Moro, 5, 00187 Rome, Dipartimento di Chimica, Sapienza Universita di Roma, P.le A. Moro, 5, 00187 Rome, Department of Biochemistry, Sanandaj Branch, Islamic Azad University, Sanandaj

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