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Synthesis and Anticancer Studies of Novel N-benzyl Pyridazino ne Derivatives

[ Vol. 14 , Issue. 9 ]

Author(s):

Mohamed Elagawany, Mohamed A. Ibrahim, Tarek S. Ibrahim, Amany M.M. AL-Mahmoudy, Alaa Moawad, Mohammed M. Ghoneim, Mohamed M. Radwan and Siva S. Panda   Pages 1008 - 1013 ( 6 )

Abstract:


Introduction: According to WHO, cancer is one of the most leading causes of death. Development of anticancer drugs draw considerable attention. Pyridazinones analogues were reported to possess anticancer properties. Chemical modification of pyridazinone may lead to potential anticancer agent.

Objective: The objective of this article is to develop new pyridazinone deriatives and evaluate their anticancer activities.

Results: The target compounds were synthesized using Palladium cross coupling reactions, Buchwald and Suzuki, the synthesized compound were evaluated against BT-549, KB and SK-MEL cell lines. Some compounds showed moderate to significant inhibitory activity.

Conclusion: Novel pyridazinone derivatives were synthesized in a good yield. Some of the synthesized analogues showed good anticancer properties against BT-549, KB and SK-MEL cell lines.

Keywords:

Anticancer, pyridazinone, suzuki, buwald coupling, anti-inflammatory, cardiovascular activities.

Affiliation:

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Damanhour University, Damanhour, Department of Pharmaceutical Chemistry, Almaarefa Colleges for Science and Technology, Riyadh 11597, Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Faculty of Pharmacy, Misr University for Science and Technology, Al-Motamayez District, P.O. Box: 77, Giza, Department of Pharmacognosy, Faculty of Pharmacy, the University of Al-Azhar, Cairo 11884, National Center for Natural Products Research, University of Mississippi, University, MS 38677, Department of Chemistry & Physics, Augusta University, Augusta, GA 30912

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