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p42.3 in Gastric Carcinoma: A Novel Biomarker and Promising Therapeutic Target

[ Vol. 14 , Issue. 10 ]

Author(s):

Hui Jing, Lu-Lu Wei, Fu-Chun Huo, Xin Ren, Jun-Nian Zheng* and Dong-Sheng Pei*   Pages 1221 - 1225 ( 5 )

Abstract:


Objective: To explore the function of p42.3 in gastric carcinoma.

Methods: We summarized the intricate regulation of p42.3 in gastric carcinoma from several aspects, namely, the structure features, the expression level, its regulation on cell cycle and EMT, its relationship with miR-29a as well as the optimal feedback circuit involved in.

Results: We addressed the complex functions of p42.3 in regulating EMT, migration, invasion, proliferation and the optimal regulation network in GC, as well as the significant up/down-stream signal molecules involved in the pathway. We have also illuminated that miR-29a can inhibit cell proliferation and block the cell cycle, at least in part, via the repression of p42.3.

Conclusion: In short, p42.3 might serve as a potential therapeutic target in the treatment of GC.

Keywords:

p42.3, gastric carcinoma, cell cycle, EMT, miR-29a, therapeutic target.

Affiliation:

Jiangsu Key Laboratory of Biological Cancer Therapy, Xuzhou Medical University, Xuzhou 221002, Department of Pathology, Xuzhou Medical University, Xuzhou 221002, Jiangsu Key Laboratory of Biological Cancer Therapy, Xuzhou Medical University, Xuzhou 221002, Jiangsu Key Laboratory of Biological Cancer Therapy, Xuzhou Medical University, Xuzhou 221002, Department of pathology, Xuzhou Medical University, Xuzhou 221000, China, 209 Tongshan Road, Xuzhou, Jiangsu, Department of pathology, Xuzhou Medical University, Xuzhou 221000, China, 209 Tongshan Road, Xuzhou, Jiangsu

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