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The Impact of 5-Substituted Uracil Derivatives on Immortalized Embryo Lung Cells

[ Vol. 14 , Issue. 12 ]

Author(s):

Natalia N. Kabal'nova, Stanislav A. Grabovskiy*, Nadezhda M. Andriayshina, Vladislav I. Egorov, Lenar R. Valiullin, Alexey A. Nabatov, Ivan S. Raginov and Yurii I. Murinov   Pages 1409 - 1414 ( 6 )

Abstract:


Background: Pyrimidine-based drugs stimulate tissue regeneration and immunity, two components that need to be improved in a number of respiratory diseases of different etiology (e.g. influenza and asthma). In the present study we investigated relationships between the character of substitutions in the uracil structure and the impact of the respective uracil derivatives on the immortalized lung cells.

Methods: The level of cell proliferation, maximum tolerated dose and toxic effect of 5-substituted uracil derivatives (12 compounds) were studied on the immortalized lung epithelial cells and compared with the ones of 6-methyluracil.

Results: 5-Carboxyuracil and 1,3-dimethyl-5-carboxyuracil had the lowest cytotoxicity among the studied compounds. Their maximal tolerated dosage values were 5 times higher whereas the proliferation index was increased by 25% and 75%, respectively, compared to 6-methyluracil, known for its positive effects on cell regeneration.

Conclusion: 5-Carboxyuracil and 1,3-dimethyl-5-carboxyuracil have the best perspectives for further studies on their biological effects.

Keywords:

Lung epithelial cells, proliferation, cytotoxicity, 5-substituted uracil derivatives, epithelial cells, etiology.

Affiliation:

Ufa Institute of Chemistry of the Russian Academy of Sciences, 450054, Ufa, Ufa Institute of Chemistry of the Russian Academy of Sciences, 450054, Ufa, Ufa Institute of Chemistry of the Russian Academy of Sciences, 450054, Ufa, Federal Center for Toxicological, Radiation and Biological Safety, 420011, Kazan, Federal Center for Toxicological, Radiation and Biological Safety, 420011, Kazan, Volga Region State Academy of Physical Culture, Sport and Tourism, 420138, Kazan, Kazan State Medical University, Kazan, 420012 , Ufa Institute of Chemistry of the Russian Academy of Sciences, 450054, Ufa

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