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Antimicrobial Activity and Molecular Docking of Tannins from Pimenta dioica

[ Vol. 15 , Issue. 5 ]

Author(s):

Reham Al-Harbi, Mona Shaaban*, Razan Al-wegaisi, Fatma Moharram, Ola Abd El-Rahman and Shahenda El-Messery   Pages 508 - 515 ( 8 )

Abstract:


Background: High rate of bacterial infection potentiates scientists to search natural products for new antimicrobial agents.

Methods: This research determines the antimicrobial activity of tannins isolated from Pimenta dioica leaves on Gram-positive and Gram-negative infectious organisms using agar diffusion method.

Results: All tested compounds were effective against Staphylococcus epidermidis, particularly pedunculagin and nilocitin exhibited broad spectrum antibacterial effects against tested isolates as quantified by microtiter plate dilution method.

Conclusion: This will open the era for in-vivo assessment of such compounds for clinical applications.

Keywords:

Antimicrobial activity, pedunculagin, nilocitin, molecular docking, Pimenta dioica, tannins.

Affiliation:

Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Taibah University, Al Madinah Al Munawarah, Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Taibah University, Al Madinah Al Munawarah, Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Taibah University, Al Madinah Al Munawarah, Department of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Pharmacy, Taibah University, Al Madinah Al Munawarah 30078, Microbiology and Immunology Department, Faculty of Pharmacy (girls), Azhar University, Cairo, Department of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Pharmacy, Taibah University, Al Madinah Al Munawarah 30078

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