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Microwave-promoted Synthesis of S-substituted Quinazoline Derivatives using 1,4-dihydroquinazoline-2-thiol

[ Vol. 15 , Issue. 6 ]


Satya Karuna Pulakhandam, Naresh Kumar Katari* and Ravi Prakash Reddy Manda   Pages 583 - 589 ( 7 )


A novel, rapid and efficient microwave-assisted synthesis of S-substituted quinazoline derivatives was obtained using 1,4-dihydroquinazoline-2-thiol and various boronic acids with copper catalyst in one-pot reactions. The versatility of the synthetic protocol with various boronic acids and the optimization processes of the microwave irradiation conditions including temperature, solvent, and reaction time were demonstrated.


Chan-Lam coupling, quinazoline, boronic acid, microwave irradiation, copper acetate, one-pot reactions.


Jawaharlal Nehru Technological University Kakinada, Kakinada, Andhra Pradesh 533 003, Department of Chemistry, GITAM School of Technology, GITAM University, HTP Campus, Rudraram, Medak, Telangana 502 329, C-MET, IDA Phase II, Cherlapally HCL (PO), Hyderabad, Telangana 500 057

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