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Novel Azole-Functionalited Flouroquinolone Hybrids: Design, Conventional and Microwave Irradiated Synthesis, Evaluation as Antibacterial and Antioxidant Agents

[ Vol. 15 , Issue. 1 ]

Author(s):

Meltem Mentese, Neslihan Demirbas*, Arif Mermer, Serpil Demirci, Ahmet Demirbas and Faik Ahmet Ayaz   Pages 46 - 64 ( 19 )

Abstract:


Background: The synthesis of new hybrid molecules consisting of several heterocyclic pharmacophores namely fluoroquinolone, 1,2,4-triazole, 1,3,4-oxadiazole and piperazine was carried out by conventional and successfully optimized microwave mediated techniques.

Methods: The structures of new compounds were confirmed using spectroscopic techniques. These compounds were screened for their antibacterial activity against E. coli, P. aeruginosa, Y. pseudotuberculosis, S. aureus, E. faecalis, B. cereus and M. smegmatis.

Results and Conclusion: Fourteen of these hybrids exhibited excellent antibacterial activities on the test microorganisms when compared with ampicillin with the mic values varying between 0.03- 0.25 µg/mL.

Keywords:

Fluoroquinolone, 1, 2, 4-triazole, 1, 3, 4-oxadiazole, piperazine, antibacterial activity, antioxidant activity, microwave.

Affiliation:

Department of Chemistry, Karadeniz Technical University, 61080 Trabzon, Department of Chemistry, Karadeniz Technical University, 61080 Trabzon, Department of Chemistry, Karadeniz Technical University, 61080 Trabzon, Department of Medical Services and Techniques, Giresun University, Vocational High School of Health Service, 28100 Giresun, Department of Chemistry, Karadeniz Technical University, 61080 Trabzon, Department of Biology, Karadeniz Technical University, 61080, Trabzon

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