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Antimicrobial Activities of Synthetic Arylidine Nicotinic and Isonicotinic Hydrazones

[ Vol. 15 , Issue. 10 ]

Author(s):

Muhammad Hayat, Khalid Mohammed Khan*, Sumayya Saeed, Uzma Salar, Momin Khan, Taimoor Baig, Aqeel Ahmad, Shahnaz Parveen and Muhammad Taha   Pages 1057 - 1067 ( 11 )

Abstract:


Background: Despite availability of variety of antibacterial agents, re-emergance of pathogenic bacteria is still a serious medical concern. Identification of new, safer, and selective antibacterial agents is the key interest in the medicinal chemistry research.

Methods: A library of synthetic arylidene nicotinic and isonicotinic hydrazones (1-63) were investigated for antimicrobial activities.

Results: A number of derivatives showed significant to moderate antimicrobial activities against Gram positive and Gram negative bacterial cultures. Few compounds also showed antifungal activity against fungal cultures. Minimum Inhibitory Concentration (MIC) was calculated for the most active compounds 1, 7, 11, 19, 34, 46, 50, 51, and 55 against gram positive and gram negative cultures.

Conclusion: Newly identified compounds may serve as lead for future research in order to get the more powerful antibacterial agents.

Keywords:

Nicotinic hydrazones, isonicotinic hydrazones, in vitro, antimicrobial activity, MIC, antifungal.

Affiliation:

Department of Chemistry, University of Karachi, Karachi-75270, H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Department of Chemistry, University of Karachi, Karachi-75270, H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Department of Chemistry, Abdul Wali Khan University, Mardan-23200, KPK, Department of Microbiology, University of Karachi, Karachi-75270, Department of Microbiology, University of Karachi, Karachi-75270, PCSIR Laboratories Complex, Shahrah-e-Dr. Salimuzzaman Siddiqui, Karachi-75280, Department of Clinical Pharmacy, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam

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