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Synthesis and Mosquitocidal Activity of a Series of Hydrazone Derivatives against Aedes aegypti

[ Vol. 15 , Issue. 6 ]

Author(s):

Mehlika Dilek Altintop*, Nurhayat Tabanca, James J. Becnel, Jeffrey R. Bloomquist, Zafer Asim Kaplancikli and Ahmet Ozdemir   Pages 671 - 677 ( 7 )

Abstract:


Background: Aedes aegypti is an important mosquito vector for the transmission of several infectious diseases. Current insecticides play a vital role in controlling mosquitoes; however, the frequent use of insecticides has led to the development of insecticide resistance. In order to control mosquito populations, new and effective bioactive molecules are urgently needed.

Methods: In the current work, N-(benzylidene)-3-cyclopentylpropionic acid hydrazide derivatives (2a-p) were synthesized and evaluated for their larvicidal and adulticidal effects on Ae. aegypti.

Results: N-(Benzylidene)-3-cyclopentylpropionic acid hydrazide (2a) and N-(4-isopropylbenzylidene)- 3-cyclopentylpropionic acid hydrazide (2i) were identified as the most potent larvicides in this series with LC50 values of 0.0097 (0.005-0.017, 95%CI) µg/µL and 0.2729 (0.223- 0.336, 95%CI) µg/µL, respectively against 1st instar A. aegypti. On the other hand, compounds 2a-p showed weak adulticidal activity against adult female A. aegypti.

Conclusion: Due to their notable larvicidal activity, compounds 2a and 2i stand out as promising candidates for further studies.

Keywords:

Hydrazone, mosquito control, insecticidal activity, dengue fever, Zika virus, larvicidal effects.

Affiliation:

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskisehir, Department of Entomology and Nematology, Emerging Pathogens Institute, University of Florida, Gainesville, FL 32610, USDA, ARS, Center for Medical, Agricultural, and Veterinary Entomology, Gainesville, FL 32608, Department of Entomology and Nematology, Emerging Pathogens Institute, University of Florida, Gainesville, FL 32610, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskisehir, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskisehir

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