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In Vitro Cytotoxic Activities of Platinum(II) Complex with 1-Methyl-2-(3'- hydroxypropyl)benzimidazole and 2-(3'-Hydroxypropyl)benzimidazolium Hexa- and Tetrachloroplatinate Salts

[ Vol. 15 , Issue. 1 ]

Author(s):

Gokcen Eren*, Sukran Yilmaz and Fatma Gumus*   Pages 65 - 69 ( 5 )

Abstract:


Background: Platinum complexes as antitumor agents have received considerable attention due to the clinically approved and have been marketed worldwide such as cisplatin, carboplatin, oxaliplatin or marketed locally such as nedaplatin, lobaplatin and heptaplatin for treatment of various tumor diseases. However, those drugs still had their own defects and they exhibited side effects including nephrotoxicity, ototoxicity, neurotoxicity and bone marrow suppression. Therefore there is still continuing interest in the development of new platinum drugs avoiding their inherent resistance and toxicity.

Methods: Two hexa- and tetrachloroplatinate salts and one platinum(II) complex were synthesized and evaluated for their in vitro cytotoxicities against human HeLa, MCF-7, and MDA-MB-231 cell lines by the MTT assay.

Results: The growth inhibitory effect values of compounds 1-3, and cisplatin against the cell lines were expressed as inhibition %.

Conclusion: Compound 3 showed appreciable activity for all examined cell lines compared to that of reference compound cisplatin.

Keywords:

Platinum complex, benzimidazole, cytotoxic activity, in vitro, DNA, RNA.

Affiliation:

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, Ankara, Cell and Virus Bank Department, Foot and Mouth Disease Institute, Ankara, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, Ankara

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