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Synthesis and Bioevaluation of Shikonin Derivatives

[ Vol. 15 , Issue. 9 ]

Author(s):

Sufen Cao, Jiangang Zhang and Wenhu Duan*   Pages 945 - 950 ( 6 )

Abstract:


Background: Ester and amide derivatives of shikonin were synthesized to improve the chemical stability of shikonin.

Methods: All synthesized compounds were evaluated for their antiproliferative activity against A549 cell line by SRB assay, and five of them demonstrated comparable cytotoxicity to shikonin.

Results and Conclusion: The most potent compound, 22d, was more stable and potent than shikonin.

Keywords:

Amidation, chemical stability, cytotoxicity, esterification, shikonin derivatives, synthesis, SRB assay, cell lines.

Affiliation:

Department of Pharmaceutical Sciences, School of Pharmacy, East China University of Science and Technology, Shanghai, Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, Department of Pharmaceutical Sciences, School of Pharmacy, East China University of Science and Technology, Shanghai

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