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Synthesis of a Series of Chalcones and Related Flavones and Evaluation of their Antibacterial and Antifungal Activities

[ Vol. 16 , Issue. 1 ]

Author(s):

Hind Benouda, Btissam Bouchal, Allal Challioui, Abdelkader Oulmidi, Tarik Harit, Fouad Malek, Abdelkhalek Riahi, Mohammed Bellaoui* and Boufelja Bouammali*   Pages 93 - 100 ( 8 )

Abstract:


Background: A series of chalcones and flavones were synthesized from 2’-hydroxyacetophenone and substituted aromatic aldehydes via Simmons-Schmidt condensation followed by oxidative cyclization.

Methods: Characterization of the obtained structures was established on the basis of their spectroscopic data. The synthesized compounds were screened for their antimicrobial activities against five bacterial strains (Citrobacter freundii, Staphylococcus aureus, Listeria monocytogenes, Salmonella braenderup, Escherichia coli.) and two fungal strains (Candida albicans, Candida krusei).

Results: The in vitro bioassay results indicated that some target compounds displayed moderate (4d, 4e) to high (4a) antifungal activity against the pathogenic fungi C. albicans and C. krusei.

Conclusion: For the antibacterial activity, only products 3d and 4d showed a weak antibacterial activity. These compounds can lead to the design of new drugs with specific antifungal activity.

Keywords:

Antibacterial activity, antifungal activity, chalcones, flavones, simmons-schmidt condensation, fluconazole.

Affiliation:

Laboratory of Organic Chemistry, Macromolecular and Natural Products, Faculty of Science, Mohammed First University, Oujda, Genetics Unit, Faculty of Medicine and Pharmacy, Mohammed First University, Oujda, Laboratory of Organic Chemistry, Macromolecular and Natural Products, Faculty of Science, Mohammed First University, Oujda, Laboratory of Organic Chemistry, Macromolecular and Natural Products, Faculty of Science, Mohammed First University, Oujda, Laboratory of Organic Chemistry, Macromolecular and Natural Products, Faculty of Science, Mohammed First University, Oujda, Laboratory of Organic Chemistry, Macromolecular and Natural Products, Faculty of Science, Mohammed First University, Oujda, Universite de Reims Champagne-Ardenne, Institut de Chimie Moleculaire de Reims (ICMR)-Groupe Methodologie en Synthese Organique, CNRS UMR 6229, Bât. Europol'Agro-Moulin de la Housse, BP 1039, 51687 Reims Cedex 2, Genetics Unit, Faculty of Medicine and Pharmacy, Mohammed First University, Oujda, Laboratory of Organic Chemistry, Macromolecular and Natural Products, Faculty of Science, Mohammed First University, Oujda

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