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Genoprotective Effect of New Triazine Derivatives in Endosulfan Mediated Toxicity, an In vivo and In vitro Study

[ Vol. 16 , Issue. 1 ]

Author(s):

Nima Naderi, Seyed Mostafa Ghasemi Najarkolaee, Mona Modanlookordi, Mohammad Shokrzadeh and Hamid Irannejad*   Pages 52 - 57 ( 6 )

Abstract:


Background: Recently, we reported synthesis and neuroprotective activity of some new 1,2,4-triazine derivatives against H2O2 and β-amyloid toxicity in two neurotic cell lines, SHSY5Y and PC12.

Methods: The promising results obtained prompted us to further study on these potent neuroprotective agents. In the current study, in vivo anti-inflammatory effect and also genoprotective activity of these compounds in endosulfan-mediated toxicity were investigated. Compounds RT and SMO exhibited high anti-inflammatory effect at 3 and 4 hours after injection in 20 mg/kg, and were even more effective than Indomethacin (20 mg/kg).

Results: Interestingly, compound SMO in 200 µM was the best compound in reducing micronuclei significantly (P value <0.0001) in lymphocytes treated with endosulfan compared to control group.

Conclusion: Herein, we report SMO as a genoprotective agent and a new drug candidate for endosulfan mediated toxicity.

Keywords:

Genoprotection, 1, 2, 4-triazine, anti-inflammatory, endosulfan, neuroprotective, neurotic cell lines.

Affiliation:

Department of Pharmacology & Toxicology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Department of Pharmacology & Toxicology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Department of Pharmacology & Toxicology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari

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