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Synthesis and Cytotoxicity Studies on Novel Piperazinylacetamides

[ Vol. 16 , Issue. 1 ]

Author(s):

Eman Bobtaina, Enise Ece Gurdal*, Irem Durmaz, Rengul Cetin Atalay and Mine Yarim   Pages 45 - 51 ( 7 )

Abstract:


Background: In this study, nine novel compounds, bearing N-[2-(4-substituted piperazine-1-yl)acetyl]-N’-[bis-(4-fluorophenyl)methyl]piperazine structures were synthesized.

Methods: Their cytotoxic properties were evaluated in vitro by NCI-60 Sulforhodamine B (SRB) assay against human cancer cell lines: Huh7 (hepatocellular), MCF7 (breast) and HCT116 (colorectal).

Results and Conclusion: According to the activity data, most of the compounds are more cytotoxic than 5-fluorouracil against Huh7 and HCT116 cancer cell lines.

Keywords:

Acetamide, anticancer, benzhydrylpiperazine, cytotoxicity, piperazine, sulforhodamine B.

Affiliation:

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Benghazi University, Belooan, Benghazi, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Yeditepe University, 34755, Kayisdagi, Istanbul, Bioinformatics Department, Graduate School of Informatics, Middle East Technical University, Ankara, Bioinformatics Department, Graduate School of Informatics, Middle East Technical University, Ankara, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Yeditepe University, 34755, Kayisdagi, Istanbul

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