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Synthesis, Characterization, Free-radical Scavenging Capacity and Antioxidant Activity of Novel Series of Hydrazone, 1,3,4-oxadiazole and 1,2,4- triazole Derived from 3,5-dimethyl-1H-pyrazole

[ Vol. 16 , Issue. 7 ]

Author(s):

Khalid Karrouchi*, Saad Fettach, Smaail Radi*, El bekkaye Yousfi, Jamal Taoufik, Yahia Nasser Mabkhot, Seham Alterary, My El Abbes Faouzi and Muhammed Ansar   Pages 712 - 720 ( 9 )

Abstract:


Background: Pyrazole is an important class of heterocyclic compound, has been shown to exhibit diverse biological and pharmacological activities such as anti-inflammatory, anti-cancer, antioxidant, etc.

Methods: In this study, a series of novel 3,5-dimethyl-1H-pyrazole derivatives containing hydrazine 4a-l have been synthesized via the reaction of the 2-(3,5-dimethyl-1H-pyrazol-1-yl)acetohydrazide. All synthesized compounds have been tested for their in vitro antioxidant activities via utilization of 1,1-biphenyl-2-picrylhydrazyl (DPPH) as a free radical scavenging reagent.

Results: The data reported herein indicates that compound 4k showed potential radical scavenging capacity and compounds 4f and 4g exhibited best activity for the iron binding while comparing with positive controls.

Conclusion: Good activity was noted for some compounds. In particular, compound 4k showed the highest antioxidant activity with IC50 values of 22.79 ± 3.64 and 1.35 ± 0.66 μg/mL in the DPPH and ABTS tests, respectively.

Keywords:

Synthesis, 3, 5-dimethyl-1H-pyrazole, 1, 3, 4-oxadiazole, 1, 2, 4-triazole, DPPH, ABTS, metal chelating activity.

Affiliation:

Medicinal Chemistry Laboratory, Faculty of Medicine and Pharmacy, Mohammed V University, 10100 Rabat, Laboratory of Pharmacology and Toxicology, Pharmacokinetic Research Team, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, LCAE, Department of Chemistry, Faculty of Sciences, Mohamed I University, 60000 Oujda, ISPITS Oujda, Nursing School Oujda, Oujda, Medicinal Chemistry Laboratory, Faculty of Medicine and Pharmacy, Mohammed V University, 10100 Rabat, Departement of Pharmaceutical Chemistry, College of Pharmacy, King Khalid University, Abha, Department of Chemistry, Faculty of Science, King Saud University, 11451 Riyadh, Laboratory of Pharmacology and Toxicology, Pharmacokinetic Research Team, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Medicinal Chemistry Laboratory, Faculty of Medicine and Pharmacy, Mohammed V University, 10100 Rabat

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