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Synthesis, Characterization, Free-radical Scavenging Capacity and Antioxidant Activity of Novel Series of Hydrazone, 1,3,4-oxadiazole and 1,2,4- triazole Derived from 3,5-dimethyl-1H-pyrazole

[ Vol. 16 , Issue. 7 ]

Author(s):

Khalid Karrouchi*, Saad Fettach, Smaail Radi, El bekkaye Yousfi, Jamal Taoufik, Yahia N. Mabkhout, Seham Alterary, My El Abbes Faouzi and M`hammed Ansar   Pages 712 - 720 ( 9 )

Abstract:


Background: Pyrazole is an important class of heterocyclic compound, has been shown to exhibit diverse biological and pharmacological activities such as anti-inflammatory, anti-cancer, antioxidant, etc.

Methods: In this study, a series of novel 3,5-dimethyl-1H-pyrazole derivatives containing hydrazine 4a-l have been synthesized via the reaction of the 2-(3,5-dimethyl-1H-pyrazol-1-yl)acetohydrazide. All synthesized compounds have been tested for their in vitro antioxidant activities via utilization of 1,1-biphenyl-2-picrylhydrazyl (DPPH) as a free radical scavenging reagent.

Results: The data reported herein indicates that compound 4k showed potential radical scavenging capacity and compounds 4f and 4g exhibited best activity for the iron binding while comparing with positive controls.

Conclusion: Good activity was noted for some compounds. In particular, compound 4k showed the highest antioxidant activity with IC50 values of 22.79 ± 3.64 and 1.35 ± 0.66 µg/mL in the DPPH and ABTS tests, respectively

Keywords:

Synthesis, 3, 5-dimethyl-1H-pyrazole, 1, 3, 4-oxadiazole, 1, 2, 4-triazole, DPPH, ABTS, Metal chelating activity.

Affiliation:

Faculty of Medicine and Pharmacy, Mohammed V University, Medicinal Chemistry Laboratory, Laboratory of Pharmacology and Toxicology, Pharmacokinetic Research Team, Faculty of Medicine and Pharmacy, University Mohammed V, Rabat, Faculty of Sciences, Mohamed I University, Department of Chemistry, Institution Superieure des Professions Infirmieres et Techniques de Sante, ISPITS, Faculty of Medicine and Pharmacy, Mohammed V University, Medicinal Chemistry Laboratory, Faculty of Science, King Saud University, Department of Chemistry, Faculty of Science, King Saud University, Department of Chemistry, Laboratory of Pharmacology and Toxicology, Pharmacokinetic Research Team, Faculty of Medicine and Pharmacy, University Mohammed V, Rabat, Faculty of Medicine and Pharmacy, Mohammed V University, Medicinal Chemistry Laboratory



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