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Design and Synthesis of Benzopyranopyrimidinyl Phosphonates as Cytotoxic and Antioxidant Agents

[ Vol. 16 , Issue. 7 ]

Author(s):

Sarva Santhisudha, Gundluru Mohan, Tenkayala Sobha Rani, Peddaiahgari Vasu Govardhana Reddy and Cirandur Suresh Reddy*   Pages 721 - 733 ( 13 )

Abstract:


Background: A concatenation of bioactive diethyl(2-hydroxyphenylsubstituted) benzopyrano pyrimidinyl phosphonates were synthesized under eco-friendly green conditions in the presence of palladium doped graphitic carbon nitride (Pd@g-C3N4) as catalyst.

Methods: The title compounds were evaluated for cytotoxic activity against MCF-7, SW-480, HeLa and HL-7702 cell lines and in-vitro antioxidant activity by DPPH, NO and H2O2 methods.

Results: The synthesized compounds manifested robust cytotoxic and antioxidant activities.

Conclusion: Some of them showed much higher bioactivity than the standards.

Keywords:

Benzopyranopyrimidinyl phosphonates, one-pot, green synthesis, Pd@g-C3N4, anticancer activity, SRB assay, antioxidant activity, in vitro.

Affiliation:

Department of Chemistry, Dravidian University, 517 426 Kuppam, Organic and Medicinal Chemistry Division, Department of Chemistry, Sri Venkateswara University, 517 502 Tirupati, Department of Chemistry, Dravidian University, 517 426 Kuppam, Department of Chemistry, Yogi Vemana University, 516 003 Kadapa, Organic and Medicinal Chemistry Division, Department of Chemistry, Sri Venkateswara University, 517 502 Tirupati

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