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Design and Synthesis of Benzopyranopyrimidinyl Phosphonates as Cytotoxic and Antioxidant Agents

[ Vol. 16 , Issue. 7 ]

Author(s):

Sarva Santhisudha, Gundluru Mohan , Tenkayala Sobha Rani, Peddaiahgari Vasu Govardhana Reddy and Cirandur Suresh Reddy   Pages 721 - 733 ( 13 )

Abstract:


Background: A concatenation of bioactive diethyl(2-hydroxyphenylsubstituted) benzopyrano pyrimidinyl phosphonates were synthesized under eco-friendly green conditions in the presence of palladium doped graphitic carbon nitride (Pd@g-C3N4) as catalyst.

Methods: The title compounds were evaluated for cytotoxic activity against MCF-7, SW-480, HeLa and HL-7702 cell lines and in-vitro antioxidant activity by DPPH, NO and H2O2 methods.

Results: The synthesized compounds manifested robust cytotoxic and antioxidant activities.

Conclusion: Some of them showed much higher bioactivity than the standards.

Keywords:

Benzopyranopyrimidinyl phosphonates, one-pot, green synthesis, Pd@g-C3N4, anticancer activity, SRB assay, antioxidant activity, in vitro.

Affiliation:

Department of Chemistry, Dravidian University, Kuppam - 517 426, Organic and Medicinal Chemistry Division, Department of Chemistry, Sri Venkateswara University, Tirupati - 517 502, Department of Chemistry, Dravidian University, Kuppam - 517 426, Department of Chemistry, Yogi Vemana University, Kadapa -516 003, Organic and Medicinal Chemistry Division, Department of Chemistry, Sri Venkateswara University, Tirupati - 517 502



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