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A One-pot Multicomponent ‘Click’ Approach to the Synthesis of Novel Tamoxifen-triazole Conjugates using Nano Iron Oxide Catalyst and their Preliminary Antiproliferative Activity Studies

[ Vol. 16 , Issue. 8 ]

Author(s):

Mohana Rao Katiki*, Dileep Kommula, Sowjanya Polepalli, Nishant Jain and Madugula Sree Rama Murty*   Pages 846 - 860 ( 15 )

Abstract:


Background: In an effort to establish new drug candidates with improved antiproliferative activity, we report here a novel class of compounds designed rationally by the replacement of an ethyl group in tamoxifen with a methylene (1H-1,2,4-triazole) and the introduction of 1,4- substituted 1,2,3-triazoles in the basic side chain.

Methods: Magnetically separable iron oxide nanoparticles have been found to effectively catalyze the one-pot multicomponent click synthesis of 1,4-disubstituted 1,2,3-triazole conjugates in water. IR, 1HNMR, 13CNMR and HRMS experiments have been implemented for the unmistakable determination of the regiochemistry of the process. The novel compounds were evaluated for their antiproliferative activity against four human tumor cell lines, namely, MCF-7, MDA-MB-231, HeLa, and A549. Cell growth inhibition was assessed according to the standard Sulforhodamine B (SRB) cell proliferation method.

Results: The most active compounds 4h, 4n and 5a have been identified with superior GI50 values in the range of 0.13–0.31 µM as compared with the reference drug, tamoxifen (0.25-0.72 µM).

Conclusion: Additionally, taking the stereochemistry into consideration, E isomers seem slightly more active towards the tested cancer cell lines with respect to Z isomers.

Keywords:

Tamoxifen, triazole, click chemistry, nano iron oxide, antiproliferative activity, stereochemistry.

Affiliation:

Medicinal Chemistry & Pharmacology Division, Discovery Laboratory, CSIR–Indian Institute of Chemical Technology, Hyderabad-500 007, Medicinal Chemistry & Pharmacology Division, Discovery Laboratory, CSIR–Indian Institute of Chemical Technology, Hyderabad-500 007, Centre for Chemical Biology, CSIR–Indian Institute of Chemical Technology, Hyderabad- 500 007, Centre for Chemical Biology, CSIR–Indian Institute of Chemical Technology, Hyderabad- 500 007, Medicinal Chemistry & Pharmacology Division, Discovery Laboratory, CSIR–Indian Institute of Chemical Technology, Hyderabad-500 007

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