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Synthesis of 3-Arylindazole-1-acetic Acids and In Vitro Study of Potential Antibacterial Effect

[ Vol. 16 , Issue. 4 ]

Author(s):

Fauzia Anjum Chattha, Samina Kousar, Mehr-un-Nisa and Munawar Ali Munawar*   Pages 401 - 407 ( 7 )

Abstract:


Background: Indazoleacetic acids and their pharmaceutically acceptable salts have been claimed to be useful as anti-inflammatory, analgesic and antipyretic agents. They are active in the treatment of respiratory diseases such as asthma, bronchitis, allergies and obstructive pulmonary diseases.

Objectives: We report herein a feasible study concerned about the design, synthesis, structure and in vitro antimicrobial activity of 3-arylindazole-1-acetic acids derivatives. Series of compounds were synthesized by alkylation of 3-arylindazoles.

Method: Synthesized compounds were subjected to study the effect on microbial growth in vitro. All synthesized compounds were found to exhibit antibacterial activities against a range of grampositive (Bacillus subtilis, Staphylococcus aureus) and gram-negative bacteria (Shigella sonnei, Escherichia coli) by broth dilution method.

Results: The synthesized compounds exhibited antibacterial activities comparable to fluoroquinolones and some compounds exhibited better activity. These findings suggest a great potential of 3-arylindazole-1-acetic acids as antibacterial compounds.

Conclusion: 3-Arylindazole-1-acetic acids are potent antimicrobial agent better than their respective 3-arylindazoles that revealed moderate activity against both gram positive and gram negative bacteria.

Keywords:

3-aryl-indazoles-1-acetic acids, inhibition, fluoroquinolones, gram positive, gram negative, indazoles.

Affiliation:

Institute of Chemistry, University of Punjab, Lahore-54590, Institute of Chemistry, University of Punjab, Lahore-54590, Department of Chemistry, University of Education, Lahore-54590, Institute of Chemistry, University of Punjab, Lahore-54590

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