Veerasamy Ravichandran*, Sivadasan Shalini, Krishnan Suresh Kumar, Harish Rajak and Ram Kishore Agrawal Pages 618 - 624 ( 7 )
Background: The development of drug-resistant by bacteria appears rapidly and thus making the effectiveness of antibiotics severely limited.
Methods: A series of thiourea derivatives was synthesized, characterized and evaluated for their in vitro antibacterial, antifungal and antiviral activities.
Results: Structures of the newly synthesized compounds were confirmed by elemental and spectral analysis. The biological results showed that some of the target compounds displayed comparable antimicrobial and antiviral activities with reference drugs. Structure-activity relationship studies revealed that the ortho- chloro or fluoro substituted phenyl at Ar1 and substituted pyridinyl at Ar2 positions of the thiourea nucleus are essential for their in vitro antimicrobial and anti-HIV activity. In particular, compounds 8 and 10 showed better activity against the tested bacteria, fungi and viral strains than other synthesized PET derivatives reported in the present study.
Conclusion: These results provide an encouraging lead that could be used for the development of new potent antiviral and antimicrobial agents.
Thioureas, antibacterial, antifungal, antiviral, anti-HIV, nucleosides.
Department of Pharmacy, AIMST University, Semeling 08100, Kedah, KMCH College of Pharmacy, Kovai Estate, Kalapatti Road, Coimbatore, Medicinal Chemistry Research Laboratory, KMCH College of Pharmacy, Coimbatore, Medicinal Chemistry Research Laboratory, SLT Institute of Pharmaceutical Sciences, Guru Ghasidas University, Bilaspur 495 009, Department of Pharmaceutical Sciences, Dr. Hari Singh Gour Vishwavidyalaya, Sagar 470003 (M.P.)