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2-Acryloyl-4,5-methylenedioxyphenol: A Small Molecule Endowed with Antidermatophytic Activity

[ Vol. 16 , Issue. 4 ]

Author(s):

Marco Zuccolo, Sabrina Dallavalle*, Raffaella Cincinelli, Luce Mattio, Stefania Mazzini, Michelandrea De Cesare and Loana Musso   Pages 461 - 466 ( 6 )

Abstract:


Background: Superficial fungal infections are the most common fungal diseases in humans, affecting more than 25% of the population worldwide.

Methods: In the present study, we have investigated the activity of kakuol, a natural compound isolated from the rhizomes of Asarum sieboldii, and some analogues, against various dermatophytes and pharmacologically relevant yeasts.

Results: One of the tested compounds, 2-acryloyl-4,5-methylenedioxyphenol, showed a broadspectrum activity against most of the fungal species assayed, resulting particularly effective against dermatophyte strains (MIC values in the range of 0.25-0.5 µg/mL, two/four-fold lower than the positive control miconazole).

Conclusion: The results suggest that this molecule can be considered a promising starting point for the development of new antifungal compounds.

Keywords:

Kakuol, Asarum sieboldii, antifungal agents, Candida albicans, dermatophytes, 3, 4-methylenedioxyphenol.

Affiliation:

Department of Food, Environmental and Nutritional Sciences, Division of Chemistry and Molecular Biology, Universita degli Studi di Milano, via Celoria 2, 20133 Milano, Department of Food, Environmental and Nutritional Sciences, Division of Chemistry and Molecular Biology, Universita degli Studi di Milano, via Celoria 2, 20133 Milano, Department of Food, Environmental and Nutritional Sciences, Division of Chemistry and Molecular Biology, Universita degli Studi di Milano, via Celoria 2, 20133 Milano, Department of Food, Environmental and Nutritional Sciences, Division of Chemistry and Molecular Biology, Universita degli Studi di Milano, via Celoria 2, 20133 Milano, Department of Food, Environmental and Nutritional Sciences, Division of Chemistry and Molecular Biology, Universita degli Studi di Milano, via Celoria 2, 20133 Milano, Department of Experimental Oncology and Molecular Medicine Fondazione IRCCS-Istituto Nazionale dei Tumori, Via Amadeo 42, 20133 Milano, Department of Food, Environmental and Nutritional Sciences, Division of Chemistry and Molecular Biology, Universita degli Studi di Milano, via Celoria 2, 20133 Milano

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