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Paclitaxel-tyroserleutide Conjugates Self-assembly into Nanocarrier for Drug Delivery

[ Vol. 16 , Issue. 8 ]

Author(s):

Yongjia Liu, Leilei Shi, Bangshang Zhu*, Yue Su, Hui Li* and Xinyuan Zhu   Pages 882 - 891 ( 10 )

Abstract:


Background: The drug-drug self-assembly was considered as a simple and efficient approach to prepare high drug loading nano-drug carriers and present new opportunities for cancer therapeutics. The strategy of PTX amphiphiles preparation would be a possible way to solve the poor water solubility of PTX.

Methods: The PTX-YSL conjugate were synthesized and characterized. The PTX-YSL nanocarriers was prepared by a simple self-assembly method. In vitro cell studies and pharmacokinetic studies were evaluated for their in vitro anti-tumor activities and blood retention time.

Results: The structures of PTX-YSL conjugate were confirmed by LC-MS, 1H NMR and FTIR. The size and morphology of the PTX-YSL self-assembled nanocarriers were observed with TEM and DLS. PTX-YSL nanocarriers could facilitate cellular uptake and had low cytotoxicity. PTX-YSL nanocarriers have longer blood retention for enhancing accumulation in the tumor tissues via EPR effect.

Conclusion: This drug delivery system formed by PTX-YSL conjugates constitutes a promising and effective drug carrier in cancer therapy.

Keywords:

Paclitaxel, tyroserleutide, self-assembly, nanocarriers, drug delivery, circular dichroism.

Affiliation:

Instrumental Analysis Center, State Key Laboratory of Metal Matrix Composites, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 200240 Shanghai, Instrumental Analysis Center, State Key Laboratory of Metal Matrix Composites, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 200240 Shanghai, Instrumental Analysis Center, State Key Laboratory of Metal Matrix Composites, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 200240 Shanghai, Instrumental Analysis Center, State Key Laboratory of Metal Matrix Composites, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 200240 Shanghai, Department of Radiology, Affiliated 6th People’s Hospital, Shanghai Jiao Tong University, 200233 Shanghai, Instrumental Analysis Center, State Key Laboratory of Metal Matrix Composites, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 200240 Shanghai

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