Nidhi Rani and Randhir Singh* Pages 512 - 521 ( 10 )
Background: A series of novel substituted 2-mercaptoimidazoles was synthesised efficiently and in high yields using one-pot synthesis from m-hydroxyacetophenones.
Methods: The structures of the newly synthesized compounds were established, their molecular activity was investigated against some bacteria and fungi were further validated using molecular docking study.
Results: Reaction of o-hydroxyphenacylbromide (2) with substituted aniline and KSCN, in the presence of catalyst p-toluene sulfonic acid afforded 4(a-r) in good yield. The structure of compounds (4a-r) was confirmed by IR, NMR and MS.
Conclusion: The compounds exhibited excellent antimicrobial potency against the tested microorganism.
Mercaptoimidazoles, imidazoles, molecular modeling, antifungal, antibacterial, m-hydroxyacetophenones.
MM School of Pharmacy, Maharishi Markandeshwar University, Sadopur-Ambala, Haryana, Department of Pharmacology, Maharishi Markandeshwar College of Pharmacy, Maharishi Markandeshwar University, Mullana- 133203, Haryana