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Progress in Synthesis and Bioactivity Evaluation of Pyrazoloquinazolines

[ Vol. 17 , Issue. 2 ]

Author(s):

Hui Zhao, Xiaoxia Hu, Yue Zhang, Chunlei Tang* and Bainian Feng*   Pages 104 - 113 ( 10 )

Abstract:


Background: This paper reviews the research progress of pyrazoloquinazolines which widely used in the field of medicine and pesticide in recent years. Five types of pyrazoloquinazolines are introduced: pyrazolo [4,3-h]quinazolines, pyrazolo[1,5-c]quinazolines, pyrazolo[4,3-f]quinazolines, pyrazolo[1,5-a] quinazolines , pyrazolo[1,5-b]quinazolines, and their new progress in the synthesis methods and treatment of diseases.

Methodology: The derivatives of pyrazoloquinazolines exhibit a wide range of pharmacological properties such as antibacterial, anticancer, antioxidants, anti-inflammatory, anti-diabetic, antiviral activities. Consequently, their syntheses have attracted significant interest. Various methodologies have been developed for the synthesis and functionalization of these class of compounds.

Conclusion: In the present article, the relevant and recent advances in the field will be briefly covered.

Keywords:

Pyrazoloquinazolines, synthesis, bioactivity, diseases, anti-inflammatory, anti-diabetic.

Affiliation:

School of Pharmaceutical Science, Jiangnan University, Wuxi 214122, School of Pharmaceutical Science, Jiangnan University, Wuxi 214122, School of Pharmaceutical Science, Jiangnan University, Wuxi 214122, School of Pharmaceutical Science, Jiangnan University, Wuxi 214122, School of Pharmaceutical Science, Jiangnan University, Wuxi 214122

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