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Novel 1,3,4-Oxadiazole Fused Thiadiazole Derivatives: Synthesis and study of Anticancer Activities

[ Vol. 16 , Issue. 6 ]

Author(s):

Zanjam Spandana, Reddymasu Sreenivasulu, Tadigiri MalathiRekhad and Mandava Venkata Basaveswara Rao*   Pages 656 - 662 ( 7 )

Abstract:


Background: In search of novel anticancer agents, a series of 1,3,4-oxadiazole derivatives (12a-j) containing 1,3,4-thiadiazole moieties were synthesized, and their structures were confirmed by 1HNMR, 13CNMR and ESI-MS spectral analysis.

Methods: Cytotoxicity of these compounds was evaluated by MTT assay in vitro against four human tumor cell lines, i.e. A549 (lung), MCF-7 (breast), A375 (melanoma) and HT-29 (colon).

Results: Here, CA4 used as positive control. Among them, compounds 12b, 12c, 12f, 12g, 12h and 12j were exhibited promising activity than control drug.

Conclusion: In conclusion, we have synthesized a novel series of 1,3,4-oxadiazole fused 1,3,4- thiazdiazole derivatives and their structures were confirmed by spectral analysis

Keywords:

Methazolamide, megazol, zibotentan, MTT assay, anticancer activity, melanoma.

Affiliation:

Department of Chemistry, Krishna University, Machilipatnam-521 001, Andhra Pradesh, India; Department of Science and Humanities, VKR,VNB & AGK Eng. College, Gudivada, Andhra Pradesh, Department of Chemistry, University College of Engineering (Autonomous), Jawaharlal Nehru Technological University, Kakinada – 533 003, Andhra Pradesh, Department of Chemistry, SPHM Kalasala, Machilipatnam – 521 001, Andhra Pradesh, Department of Chemistry, Krishna University, Machilipatnam-521 001, Andhra Pradesh



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