Zanjam Spandana, Reddymasu Sreenivasulu, Tadigiri MalathiRekha and Mandava Venkata Basaveswara Rao* Pages 656 - 662 ( 7 )
Background: In search of novel anticancer agents, a series of 1,3,4-oxadiazole derivatives (12a-j) containing 1,3,4-thiadiazole moieties were synthesized, and their structures were confirmed by 1HNMR, 13CNMR and ESI-MS spectral analysis.
Methods: Cytotoxicity of these compounds was evaluated by MTT assay in vitro against four human tumor cell lines, i.e. A549 (lung), MCF-7 (breast), A375 (melanoma) and HT-29 (colon).
Results: Here, CA4 used as positive control. Among them, compounds 12b, 12c, 12f, 12g, 12h and 12j were exhibited promising activity than control drug.
Conclusion: In conclusion, we have synthesized a novel series of 1,3,4-oxadiazole fused 1,3,4- thiazdiazole derivatives and their structures were confirmed by spectral analysis.
Methazolamide, megazol, zibotentan, MTT assay, anticancer activity, melanoma.
Department of Chemistry, Krishna University, Machilipatnam 521001, Andhra Pradesh, Department of Chemistry, University College of Engineering (Autonomous), Jawaharlal Nehru Technological University, Kakinada 533003, Andhra Pradesh, Department of Chemistry, SPHM Kalasala, Machilipatnam 521001, Andhra Pradesh, Department of Chemistry, Krishna University, Machilipatnam 521001, Andhra Pradesh