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5-Nitrofuran-2-yl Thiohydrazones as Double Antibacterial Agents Synthesis and In Vitro Evaluation

[ Vol. 17 , Issue. 3 ]

Author(s):

Alexey Yurjevich Lukin, Tatiana Sergeevna Vedekhina and Mikhail Vassiljevich Chudinov*   Pages 356 - 361 ( 6 )

Abstract:


Background: Applying of "double-drug" strategy to 5-nitrofuran derivatives has been proposed.

Methods: A small library of 5-Nitrofuran-2-yl Thiohydrazones was developed, and initial screening demonstrated good activity against bacteria and fungi of ESKAPE panel.

Results and Conclusion: The synthesis of the desired thiohydrazones was carried out via condensation of 5-nitrofuran-2-carbaldehyde with thiohydrazides of substituted oxamic acids.

Keywords:

5-Nitrofuran derivatives, thiohydrazones, double drug, health care-associated infections, bacterial resistance, CO-ADD.

Affiliation:

Biotechnology and Industrial Pharmacy Department, Lomonosov Institute of Fine Chemical Tehnologies, MIREARussian Technological University, Vernadskogo Pr. 78, 119454, Moscow, Biotechnology and Industrial Pharmacy Department, Lomonosov Institute of Fine Chemical Tehnologies, MIREARussian Technological University, Vernadskogo Pr. 78, 119454, Moscow, Biotechnology and Industrial Pharmacy Department, Lomonosov Institute of Fine Chemical Tehnologies, MIREARussian Technological University, Vernadskogo Pr. 78, 119454, Moscow

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