Methods: A small library of 5-Nitrofuran-2-yl Thiohydr"/> 5-Nitrofuran-2-Yl Thiohydrazones as Double Antibacterial Age

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5-Nitrofuran-2-Yl Thiohydrazones as Double Antibacterial Agents Synthesis and In vitro Evaluation

[ Vol. 17 , Issue. 3 ]

Author(s):

Alexey Yu. Lukin, Tatiana S. Vedekhina and Mikhail V. Chudinov*   Pages 356 - 361 ( 6 )

Abstract:


Background: Applying of "double-drug" strategy to 5-nitrofuran derivatives has been proposed.

Methods: A small library of 5-Nitrofuran-2-yl Thiohydrazones was developed, and initial screening demonstrated good activity against bacteria and fungi of ESKAPE panel.

Conclusion: The synthesis of the desired thiohydrazones was carried out via condensation of 5- nitrofuran-2-carbaldehyde with thiohydrazides of substituted oxamic acids.

Keywords:

5-Nitrofuran derivatives, thiohydrazones, double drug, health care-associated infections, bacterial resistance, COADD.

Affiliation:

Biotechnology and Industrial Pharmacy Department, Lomonosov Institute of Fine Chemical Tehnologies, MIREA-Russian Technological University, Vernadskogo Pr. 78, 119454, Moscow, Biotechnology and Industrial Pharmacy Department, Lomonosov Institute of Fine Chemical Tehnologies, MIREA-Russian Technological University, Vernadskogo Pr. 78, 119454, Moscow, Biotechnology and Industrial Pharmacy Department, Lomonosov Institute of Fine Chemical Tehnologies, MIREA-Russian Technological University, Vernadskogo Pr. 78, 119454, Moscow



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