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Bioactive Isolates of Morus Species as Antibacterial Agents and their In Silico Profiling

[ Vol. 18 , Issue. 5 ]

Author(s):

Aditya Shimoga Janakirama Rao, Venugopal Thegur Mudduraj Urs, Jayanna Nayakarahatty Devanna, Paramesha Mahadevappa and Ramesh Chapeyil Kumaran*   Pages 445 - 453 ( 9 )

Abstract:


Background: The genus Morus is one of the rich sources of phytomedicine and considered a beneficial natural source for drugs with potential antimicrobial effect under the traditional system of medicine.

Introduction: In the present study, three bioactive compounds isolated from the leaves of two species of genus Morus and their antibacterial effect against selective pathogens were assessed.

Methods: The inhibitory effects of the three molecules isolated were assessed for their minimum inhibition concentration (MIC) and minimum bactericidal concentration (MBC) against selected pathogens. The in-silico studies provided the toxicity profile and the binding interactions with glucosamine- 6-phosphate synthase for all the isolates.

Results: Among the three compounds tested, cathafuran-B showed a prominent bacteriostatic and bactericidal effect, which is supported by the results of in-silico analysis suggesting that cathafuran- B could be a potential glucosamine-6-phosphate synthase inhibitor.

Conclusion: The biomolecule isolated from less explored Morus laevigata exhibiting higher antibacterial effect among the compounds tested warranted opening a new prospect in phytomedicinal research for exploring its pharmacological properties and lowering the utilization load present on highly explored Morus alba.

Keywords:

Bacteriostatic, docking, natural products, CHARMm, glucosamine-6-phosphate synthase, Morus.

Affiliation:

Department of Biotechnology, Kuvempu University, Sahyadri Science College Campus, Shivamogga, Karnataka, Department of Microbiology, Kuvempu University, Sahyadri Science College Campus, Shivamogga, Karnataka, Department of Microbiology, Kuvempu University, Sahyadri Science College Campus, Shivamogga, Karnataka, Department of Plant Cell Biotechnology, CSIR-CFTRI, Mysore, Karnataka, Department of Biotechnology, Kuvempu University, Sahyadri Science College Campus, Shivamogga, Karnataka

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