Hiroyuki Ushio, Seigo Ishibuchi, Kunitomo Adachi, Kouichi Oshita and Kenji Chiba Pages 111 - 115 ( 5 )
In research for a new immunomodulator, we discoverd a novel hydroxypiperidine derivative 9h which was a potent inhibitor of IL-15induced T cell activation. Further modification of 9h gave a potent and orally active agent 10 which was effective in a mouse CIA model.
Phenylpyrazoleanilide, IL-15, Prodrug, CIA
Medicinal Chemistry Laboratory,Research division, Mitsubishi Tanabe Pharma Corporation, 1000,Kamoshida-cho, Aoba-ku, Yokohama 227-0033, Japan.